Store pearls separately from other jewelry pieces. This is for the protection of your pearls as well as the protection of your other jewelry items. Pearls can be easily scratched or broken, so keep them in a special area of your jewelry box or in an entirely different location. The best storage method for pearl jewelry is in a soft bag, made of silk or chamois or another soft fabric.
Additionally, you should restring pearl necklaces at least once every year or two to ensure that the cord holding the pearls together remains in tact.